Scientific creativity on a global scale

Find a way of mapping tumours at the molecular and cellular level

Decipher the functional basis underlying the association between ageing somatic tissues and cancer

Detect cancer earlier by interrogating medical and non-medical data sets using machine and deep-learning

Deliver biologically active macromolecules to any and all cells in the body

Understand and reverse cachexia and declining performance status in cancer patients

Determine the mechanisms that cause cancer without known mutagenesis, such as obesity, in order to devise novel interventions

Understand cancer cell plasticity and its contribution to the development of pan-therapeutic resistance in cancer

Understand the mechanisms through which genetics, biology, and social determinants affect cancer risk and outcomes in diverse populations, to motivate interventions to reduce cancer inequities

Understand and prevent chemotherapy-induced neurotoxicity and neuropathy

Identify and target tumour cells that remain dormant for many years after seemingly effective treatment

Identify and target dormant cancer cells

Determine the potential benefits and risks of e-cigarette use

Determine why the incidence of early-onset cancers in adults is rising globally

To eradicate EBV-induced cancers from the world

Understand the biology of ecDNA generation and action, and develop approaches to target these mechanisms in cancer

Distinguish between lethal cancers that need treating, and non-lethal cancers that don't

Systemically deliver macromolecules to intracellular targets for therapeutic benefit in cancer

Improve treatment responses by manipulating the composition and status of the microbiota

Understand how cells and tissues maintain “normal” phenotypes whilst harbouring oncogenic mutations and how they transition to become a tumour

Determine the mechanisms through which obesity and physical activity influence cancer risk

Develop vaccines to prevent non-viral cancers

Understand the roles of retrotransposable elements in cancer

Understand and exploit senescence to improve cancer treatment

Develop novel therapies to target unique features in solid tumours in children

Develop therapeutics to target oncogenic drivers of solid tumours in children

Decipher the T-cell receptor cancer-recognition code

Develop innovative approaches to target the cancer supercontroller Myc

Devise approaches to prevent or treat cancer based on mechanisms that determine tissue specificity of some cancer genes

Define mechanistic rules for combinatorial treatments to overcome resistance and avoid toxicity

Create novel tumour vaccinology approaches that establish or enhance successful immune responses beyond what is revealed by current checkpoint therapy

Discover how unusual patterns of mutation are induced by different cancer-causing events