Articles

• New Scientific Committee members announced
• Catalysing new thinking on the development of cancer
• OPTIMISTICC: New connection drives poor outcomes in bowel cancer
• Metabolic fingerprinting reveals link between dietary fat restriction and therapy response
• Nature Reviews Drug Discovery: addressing cancer’s grand challenges
• The power of discovery: 7 teams leading the way
• The Challenges: Professor Sir David Lane shares his thoughts on the macromolecules challenge
• AACR Cancer Discovery: Cancer Grand Challenges to fund broad, pressing research
• AACR Cancer Discovery In Focus: embarking on a new era of discovery
• The Challenges: Professor Crystal Mackall on the solid tumours in children challenge
• The Challenges: Professor René Bernards on the senescence challenge
• STORMing Cancer's Professor Don Ingber receives prestigious Wilbur Cross Medal
• The Challenges: Professor Karen Vousden on the normal phenotypes challenge
• Multidisciplinary collaboration driving new discoveries: uncovering the role of SLC7A5 in KRAS-driven colorectal cancer
• The Challenges: Professor Nic Jones on dormancy
• The Challenges: Ed Harlow shares his thoughts on the inflammation challenge
• News from the IMAXT team: Expansion Sequencing technology
• The Challenges: Professor Charlie Swanton discusses the cachexia challenge
• “We wanted to do everything we could to support them”: Nick and Annette Razey give £1m to back Cancer Grand Challenges team
• The Challenges: Professor Charlie Swanton discusses the extrachromosomal DNA challenge
• Professor Barbara Rimer on aspiring to create an inclusive world #IWD2021
• Michele Cleary on celebrating women in science #IWD2021
• Challenging the status quo and collaborating across disciplines in the IMAXT team #IWD2021
• The value of good mentorship: Amy Schade and Karen Cichowski celebrate #IWD2021
• Kimmie Ng and Candace Henley celebrate the value of the patient advocacy voice in cancer research #IWD2021
• Could the size of fat cells around DCIS breast lesions predict risk of future invasive cancer?
• The Challenges: Professor David Hunter shares his thoughts on e-cigarettes
• The microbiome: a biomarker for colorectal cancer?
• In conversation with Owen Sansom and Helen Matthews, SPECIFICANCER
• AACR Meet the Experts Session
• Inside Project Theia, the world’s first virtual reality cancer research lab – and a call for volunteers
• 7 Questions with... Jelle Wesseling, PRECISION
• Caitlin Brennan discusses the microbiome and aspirin's potential in personalised prevention
• Survival of the fittest: revealing the early stages of APC-driven colorectal cancer
• Announcing the shortlist for the Cancer Grand Challenges awards
• Questions with...Johanna Joyce, IMAXT
• Questions with...Mike Stratton, Mutographs
• A COSMIC catalogue of cancer data, with Mutographs' Ellie Dunstone
• IMAXT’s Nic Walton: uniting across disciplines to share learnings in data science
• Cindy Sears: the power of preclinical models and learnings from global health
• 7 Questions with... John Marioni, IMAXT
• Discover: a year of scientific creativity
• New findings, old ideas: reviving a decades old view on the causes of cancer
• Unravelling the drivers of immune evasion in head and neck cancer
• Escape from the immune system
• New thinking on the process of ageing
• A step closer to distinguishing harmless from invasive breast lesions 
• Hidden treasure: do the clues to preventing and detecting colorectal cancer lie in the microbiome?
• Matrix remodelling in the transformation from inflammation to malignancy   
• Uncharted territory: metabolic tumour maps reveal new therapeutic avenues
• Genes in space: the future of biology is spatial
• The rules (not the exceptions) of cancer tissue specificity
• “We can all be agents of change” - learnings from our first Future Leaders Conference
• Unravelling the mystery of oesophageal cancer incidence, by Mutographs’ Sarah Moody
• Unexpected findings from the Mutographs team: huge global variation in oesophageal cancer incidence is not due to a unique pattern of DNA damage
• Why virtual reality is the future
• Cancer Revolution: Science, Innovation and Hope – a world-first exhibition
• Spotlight: our work in pancreatic cancer
• Bjorn Saven: why developing the infrastructure for early career researchers to thrive will bring about meaningful change
• A better understanding of how chronic inflammation drives lung cancer
• “An inspirational year” – Saamin Cheema reflects on her first 12 months with Cancer Grand Challenges
• Spotlight: International Day of Women and Girls in Science
• Clusters of mutations: a new driver of tumour evolution
• Fusobacterium nucleatum: a driver, partner or passenger in colorectal cancer development?
• “Collectively, our work could ultimately save tens of thousands of people the burden of invasive treatment with little benefit.”
• Changing the paradigm of colorectal cancer treatment
• Cancer Grand Challenges in The Big Easy
• Do clues to breast cancer progression lie in specks seen on mammograms?
• A step closer to avoiding overtreatment in people with DCIS
• Spotlight: our work in oesophageal cancer
• A comprehensive map of cancer genomes and chromosomal changes
• Announcing 4 new teams receiving $100m to take on cancer's toughest challenges
• “We want to stop cancer before it even starts” - meet the team taking on the Normal Phenotypes challenge 
• The Cancer Cachexia Action Network - meet the team taking on the Cachexia challenge
• Bringing next-generation CAR T-cell therapies to children with solid cancers
• Cancer’s secrets uncovered from non-cancerous tissue
• Discover: a year of scientific creativity 2022
• A powerful lens into tumour metabolism
• Excavating the genes that help tumours escape the immune system
• An atlas of oesophageal cancer development
• Harnessing the microbiome to personalise colorectal cancer prevention, diagnosis and treatment
• Refuting the dogma surrounding breast cancer risk
• An entirely new way to visualise tumours
• Study suggests C. difficile drives some colorectal cancers
• "Our team’s work has hope written all over it”
• A new tool to probe mutational signatures – and the long-sought-after link between tobacco and bladder cancer
• A global search for cancer's toughest challenges
• The virtual reality tumour map that could revolutionise cancer treatment
• Team science: 2022 highlights
• Announcing nine of cancer’s toughest challenges with up to $25m funding for global research teams
• Introducing our new Scientific Committee members
• Cancer mystery as cases rise among younger people around the world
• Novel insights into the role of ecDNA in the cancerous transition of Barrett's oesophagus
• Discover: a year of scientific creativity 2023
• Spotlight on the new Cancer Grand Challenges teams
• The multifaceted approach of Cancer Grand Challenges research
• "Being a part of Cancer Grand Challenges is truly a unique experience"
• Targeting vulnerabilities of childhood cancers
• A unique resource for studying DCIS and progression to cancer
• Nine new challenges videos
• AACR Cancer Discovery In Focus: harnessing the power of discovery
• Pre-application webinar: everything you need to know about applying
• Researchers identify new mechanism of oncogene amplification in breast cancer
• Could microcalcification crystallography help to predict which DCIS cases might progress to invasive breast cancer?
• Considering the bigger picture in the treatment of cancer: new findings from the team taking on our Cachexia challenge
• Introducing the new members of the Cancer Grand Challenges Advocacy Panel
• Introducing new Scientific Committee member, Dr Tom Misteli
• The power of combining mass spectrometry techniques to interrogate the cancer metabolome
• Announcing the global teams that have been shortlisted for a Cancer Grand Challenges award
• Major new scientific partnership between the UK and France to tackle cancer’s toughest challenges
• Changing the narrative around ductal carcinoma in situ and breast cancer risk
• A holistic approach to cancer research: bringing future research leaders together with patient advocates
• Embedding patient advocacy within a discovery science initiative
• Five new teams selected to take on cancer’s toughest challenges
• Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
• A network approach reveals roles for cancer stem cells in cancer promotion