News & Insight

News
A network approach reveals roles for cancer stem cells in cancer promotion
Q&A with Professor Allan Balmain and Dr Mark Taylor on new findings from the PROMINENT team, tackling our Normal Phenotypes challenge
We talked to team PROMINENT members Professor Allan Balmain and Dr Mark Taylor from the University of California San Francisco about their latest paper ‘Stem-cell states converge in multi-stage cutaneous squamous cell carcinoma development…
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News
Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the…
News
Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…

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News
Clusters of mutations: a new driver of tumour evolution
Artificial intelligence techniques developed in response to our Unusual Mutation Patterns challenge have led to the identification of a new player in tumour evolution: clusters of mutations that aggregate at specific…
Saamin Cheema
Blog
“An inspirational year” – Saamin Cheema reflects on her first 12 months with Cancer Grand Challenges
Saamin Cheema (centre above), a recent graduate, joined the Cancer Grand Challenges Mutographs team in January 2021 as a data scientist. Here, she reflects on her first year working to help tackle the "Unusual Mutation…
Deng pan and Thea
News
A better understanding of how chronic inflammation drives lung cancer
Inflammation coaxes lung epithelial cells to be replaced by those more commonly seen in other organs - a clinically relevant event that can be studied using accurate in vitro models of the human lung. In response to…
Video
New thinking on the process of ageing
Members of the Cancer Grand Challenges Mutographs team challenge the current theory of ageing, revealing that healthy cells can tolerate many more mutations that previously assumed. What causes us to age? A popular…
Bjorn Saven card
News
Bjorn Saven: why developing the infrastructure for early career researchers to thrive will bring about meaningful change
A generous gift from industrialist and investor Bjorn Saven has helped to launch our Future Leaders Conference.  In October, we launched our inaugural Future Leaders Conference, powered by a steering committee of PhD…
Pancreatic cancer cell
News
Spotlight: our work in pancreatic cancer
Survival for pancreatic cancer remains intractably low, with just 9% of people surviving for 5 years beyond diagnosis. For World Pancreatic Cancer Day 2021, we’re shining a light on much-needed research into the disease…
Science museum image
News
Cancer Revolution: Science, Innovation and Hope – a world-first exhibition
Members of the Cancer Grand Challenges community feature in a new exhibition on cancer research from the Science Museum Group.  Cancer Revolution: Science, Innovation and Hope is the world’s first major exhibition…
Video
Why virtual reality is the future
A short film from Columbia Cancer Research featuring members of our IMAXT team – co-investigators Simon Tavaré and Owen Harris, and postdoctoral researcher Ignacio Vazquez-Garcia. Learn more about the IMAXT team.…
Mutographs esophageal paper
News
Unravelling the mystery of oesophageal cancer incidence, by Mutographs’ Sarah Moody
The Cancer Grand Challenges Mutographs team has added an unexpected piece to the complex puzzle surrounding the development of oesophageal squamous cell carcinoma (ESCC): no mutational signature exists to explain the…