News & Insight

News
A network approach reveals roles for cancer stem cells in cancer promotion
Q&A with Professor Allan Balmain and Dr Mark Taylor on new findings from the PROMINENT team, tackling our Normal Phenotypes challenge
We talked to team PROMINENT members Professor Allan Balmain and Dr Mark Taylor from the University of California San Francisco about their latest paper ‘Stem-cell states converge in multi-stage cutaneous squamous cell carcinoma development…
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Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the…
News
Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…

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AACR Cancer Discovery news story - Rene Bernards
Coverage
AACR Cancer Discovery: Cancer Grand Challenges to fund broad, pressing research
Read the latest coverage on Cancer Grand Challenges. “There’s a lot of potential to unlock, and Cancer Grand Challenges could be the key.” - Professor René Bernards A recent piece in AACR Cancer Discovery's News in…
Professor Sir David Lane
Blog
The Challenges: Professor Sir David Lane shares his thoughts on the macromolecules challenge
In October, we posed 9 new challenges to the research community, each with the potential to change the way we think about cancer. Through our new blog series, members of our Cancer Grand Challenges Scientific Committee…
Cancer Grand Challenges Summit 2020 attendees
Blog
The power of discovery: 7 teams leading the way
With our first Cancer Grand Challenges blog, we reflect on the progress of the 7 teams tackling some of cancer’s toughest challenges.  It started in 2015, with 7 audacious challenges.   Since then, we’ve supported 7…
9 colour block illustrations of cells
Coverage
Nature Reviews Drug Discovery: addressing cancer’s grand challenges
Read the latest coverage of Cancer Grand Challenges.   “All these ‘challenges’ are actually very interesting and highly worthy of the attention of the cancer research community,” says Robert Weinberg, of the Whitehead…
Credit: Jeroen Claus (Phospho Biomedical Animation)
News
Metabolic fingerprinting reveals link between dietary fat restriction and therapy response
Research from the Cancer Grand Challenges Rosetta team has identified a potential metabolic weakness in cancer that could be amenable to treatment.   The findings, published in Cell, focused on exploring whether the…
Bowel cancer cell, CRUK LRI Experimental Histopathology Unit
News
OPTIMISTICC: New connection drives poor outcomes in bowel cancer
Up to 45% of bowel cancers carry a fault in the KRAS gene, detrimentally affecting how a patient will respond to treatment. New results from the OPTIMISTICC team suggest these poor outcomes may be due to the way faulty…
Lung cancer cell, full credit to LRI EM department.
News
Catalysing new thinking on the development of cancer
Some carcinogens can cause cancer without directly damaging DNA: a new study from the Cancer Grand Challenges Mutographs team challenges a long-held view on the early development of a tumour. For years, research has…
Barbara Rimer and Jill P. Mesirov
People
New Scientific Committee members announced
The Cancer Grand Challenges Scientific Committee is pleased to welcome two new members: Professor Jill P Mesirov (University of California San Diego School of Medicine) and Professor Barbara K Rimer (University of North…