News & Insight

News
A network approach reveals roles for cancer stem cells in cancer promotion
Q&A with Professor Allan Balmain and Dr Mark Taylor on new findings from the PROMINENT team, tackling our Normal Phenotypes challenge
We talked to team PROMINENT members Professor Allan Balmain and Dr Mark Taylor from the University of California San Francisco about their latest paper ‘Stem-cell states converge in multi-stage cutaneous squamous cell carcinoma development…
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News
Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the…
News
Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…

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Video
Announcing the shortlist for the Cancer Grand Challenges awards
Nearly 170 diverse, global teams submitted bold ideas outlining how they would solve some of cancer’s toughest challenges. Today, we reveal the 11 teams selected to compete for a share of £80m.   We were delighted to…
Cancer cells
News
Survival of the fittest: revealing the early stages of APC-driven colorectal cancer
APC is one of the most commonly mutated genes in colorectal tumours – but why is it so frequently mutated in this type of cancer compared to others? The answer lies in the way APC-mutant cells compete with their…
Video
In conversation with Owen Sansom and Helen Matthews, SPECIFICANCER
Patient advocate Helen Matthews meets co-investigator Owen Sansom to discuss SPECIFICANCER’s latest findings, how working cross-discipline enables ‘big strides forward’ and the unique, important perspectives brought to…
Caitlin Brennan
News
Caitlin Brennan discusses the microbiome and aspirin's potential in personalised prevention
New findings from the OPTIMISTICC team reveal aspirin’s antibacterial activity against Fusobacterium nucleatum, an oncomicrobe known to drive colorectal cancer.   OPTIMISTICC’s Caitlin Brennan, postdoctoral fellow and…
Jelle Wesseling
News
7 Questions with... Jelle Wesseling, PRECISION
By distinguishing between people with ductal carcinoma in situ (DCIS) who will develop invasive breast cancer and those who won’t, the Cancer Grand Challenges PRECISION team could spare thousands of women around the…
Video
Inside Project Theia, the world’s first virtual reality cancer research lab – and a call for volunteers
Look inside the IMAXT team’s virtual reality lab, ahead of its release later this year, as the team calls for volunteers to help test the software.  A core component of the Cancer Grand Challenges IMAXT programme,…
cross section though the wall of the large bowel showing an ulcerated cancer growing through the bowel wall and having invaded a large vein
News
The microbiome: a biomarker for colorectal cancer?
Findings from the OPTIMISTICC team point towards a global microbiome signature for colorectal cancer that could help improve the way we detect the disease. Colorectal cancer is the third most common cancer in the world…
David Hunter
Blog
The Challenges: Professor David Hunter shares his thoughts on e-cigarettes
In October, we posed 9 new challenges to the research community, each with the potential to change the way we think about cancer. Through our blog series, members of our Cancer Grand Challenges Scientific Committee…
Video
AACR Meet the Experts Session
We recently held a webinar with the American Association for Cancer Research (AACR) providing an overview of the Cancer Grand Challenges partnership between Cancer Research UK and the US National Cancer Institute. …