News & Insight

News
A network approach reveals roles for cancer stem cells in cancer promotion
Q&A with Professor Allan Balmain and Dr Mark Taylor on new findings from the PROMINENT team, tackling our Normal Phenotypes challenge
We talked to team PROMINENT members Professor Allan Balmain and Dr Mark Taylor from the University of California San Francisco about their latest paper ‘Stem-cell states converge in multi-stage cutaneous squamous cell carcinoma development…
Read the full article

Latest

News
Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the…
News
Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…

News and insight archive

Format
Choose
Team
Choose
Tags
Choose
"Cancer Grand Challenges is an opportunity to ask the questions we always wanted to ask," Tom Misteli, Cancer Grand Challenges Scientific Committee.
People
Introducing new Scientific Committee member, Dr Tom Misteli
We are pleased to welcome Dr Tom Misteli of the National Cancer Institute’s Center for Cancer Research, USA, to the Cancer Grand Challenges Scientific Committee. Tom will join the other 14 members of the Scientific…
Introducing the new members of the Cancer Grand Challenges Advocacy Panel
People
Introducing the new members of the Cancer Grand Challenges Advocacy Panel
We are pleased to welcome seven new members to the Cancer Grand Challenges Advocacy Panel: Yelak Biru, Ivana Cattaneo, Anjee Davies, Joya Harris, Dirk Hellrung, Chris Stewart and Christine Wu. From helping to shape…
New findings from the team taking on our Cachexia challenge
News
Considering the bigger picture in the treatment of cancer: new findings from the team taking on our Cachexia challenge
New research from the Cancer Grand Challenges CANCAN team finds that a ketogenic diet slows tumour growth but shortens survival by accelerating the onset of cancer cachexia in murine models. The findings, published in…
Exploring the crystallographic and chemical features of DCIS microcalcifications
News
Could microcalcification crystallography help to predict which DCIS cases might progress to invasive breast cancer?
New research from the Cancer Grand Challenges PRECISION team, published in Scientific Reports, finds that the crystallographic and chemical features of microcalcifications present in ductal carcinoma in situ (DCIS)…
Colour-enhanced microscopy image of a breast cancer cell.
News
Researchers identify new mechanism of oncogene amplification in breast cancer
A new Nature paper from the Cancer Grand Challenges SPECIFICANCER team describes a mechanism through which oestrogen-induced DNA breaks and their repair by inter-chromosomal translocations initiate a cascade of events…
Text that says pre application webinar recording
Video
Pre-application webinar: everything you need to know about applying
In March 2023, we launched nine new challenges, with up to £20m funding for global research teams. This webinar features everything you need to know about the Cancer Grand Challenges application process Hosted by…
Nine new Cancer Grand Challenges - challenge videos
Video
Nine new challenges videos
Members of our Scientific Committee discuss each of our nine new challenges, their potential impact and what we're looking for from applications Ageing and cancer Cancer cell plasticity  Cancer inequities…
David Scott and Dinah Singer
Coverage
AACR Cancer Discovery In Focus: harnessing the power of discovery
In an ‘In Focus’ commentary article for AACR Cancer Discovery, Dr David Scott and Dr Dinah Singer discuss our nine new Cancer Grand Challenges, for which Expressions of Interest are open until 22 June 2023. In March at…
Image of Stefan Hutten alongside the article title - A unique resource for studying DCIS and progression to cancer
News
A unique resource for studying DCIS and progression to cancer
Members of the Cancer Grand Challenges PRECISION team have developed a living biobank of 115 patient-derived Mouse-INtraDuctal (MIND) ductal carcinoma in situ (DCIS) models and used them to identify risk factors…