News & Insight

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A network approach reveals roles for cancer stem cells in cancer promotion
Q&A with Professor Allan Balmain and Dr Mark Taylor on new findings from the PROMINENT team, tackling our Normal Phenotypes challenge
We talked to team PROMINENT members Professor Allan Balmain and Dr Mark Taylor from the University of California San Francisco about their latest paper ‘Stem-cell states converge in multi-stage cutaneous squamous cell carcinoma development…
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Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the…
News
Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…

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OPTIMISTICC header with photos of Kimmie, Josep and Candace
Blog
Harnessing the microbiome to personalise colorectal cancer prevention, diagnosis and treatment
Colorectal cancer incidence is increasing worldwide, particularly in people younger than 50 years, but the reason remains a mystery. In addition, the effectiveness of treatments inexplicably varies within the same…
SPECIFICANCER header with quote from Stephen Elledge
Blog
Excavating the genes that help tumours escape the immune system
Why are certain cancer genes broadly expressed throughout the body, yet they trigger cancer in only specific tissues? New findings from the team taking on our Tissue Specificity challenge suggest that the immune system…
Josephine Bunch photo
Blog
A powerful lens into tumour metabolism
Josephine Bunch reflects on a new way to map cancer.  In taking on our 3D Tumour Mapping challenge, the Cancer Grand Challenges Rosetta team has curated a suite of mass spectrometry imaging (MSI) techniques that can…
Image card of Peter Campbell
Blog
Cancer’s secrets uncovered from non-cancerous tissue
What can studying non-cancerous tissue from people with cancer teach us about a tumour? Dr Peter Campbell (Sanger Institute, Cambridge, UK), co-investigator of the team taking on our Unusual Mutation Patterns challenge…
This photograph depicted an Enteric Diseases Laboratory Branch (EDLB) public health scientist, preparing bacteria for a DNA fingerprinting test
News
Study suggests C. difficile drives some colorectal cancers
Common infection could be one driver of colorectal cancer rise in younger adults, according to findings from members of the team taking on our Microbiome challenge.   Data collected by researchers at the Johns Hopkins…
NexTGen at summit
Blog
Bringing next-generation CAR T-cell therapies to children with solid cancers
On 16 June 2022, we announced 4 new Cancer Grand Challenges teams taking on some of the toughest challenges in cancer research. Here, meet the NexTGen team receiving $25m to take on the Solid Tumors in Children…
CANCAN team at Cancer Grand Challenges summit
Blog
The Cancer Cachexia Action Network - meet the team taking on the Cachexia challenge
On 16 June 2022, we announced four new Cancer Grand Challenges teams taking on some of the toughest challenges in cancer research. Here, meet the CANCAN team receiving $25m to take on the Cachexia challenge.  Many…
PROMINENT team at the Cancer Grand Challenges summit
Blog
“We want to stop cancer before it even starts” - meet the team taking on the Normal Phenotypes challenge 
On 16 June 2022, we announced four new Cancer Grand Challenges teams taking on some of the toughest challenges in cancer research. Here, meet the PROMINENT team receiving $25m to take on the Normal Phenotypes challenge…
$100m funded - meet the new teams
News
Announcing 4 new teams receiving $100m to take on cancer's toughest challenges
Today we announce the four new teams selected to each receive $25m Cancer Grand Challenges funding to take on some of the toughest challenges in cancer research.   Representing a total investment of $100m, these are…