News & Insight

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A network approach reveals roles for cancer stem cells in cancer promotion
Q&A with Professor Allan Balmain and Dr Mark Taylor on new findings from the PROMINENT team, tackling our Normal Phenotypes challenge
We talked to team PROMINENT members Professor Allan Balmain and Dr Mark Taylor from the University of California San Francisco about their latest paper ‘Stem-cell states converge in multi-stage cutaneous squamous cell carcinoma development…
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Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the…
News
Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…

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It's been an incredible year of discoveries for Cancer Grand Challenges and we look forward to seeing what 2023 brings
Blog
Team science: 2022 highlights
Lorenzo de la Rica (@LdelaRica) is Research Portfolio Manager at Cancer Grand Challenges In 2022, we have seen our Cancer Grand Challenges (CGC) community grow, with four new teams receiving a total of $100m funding.…
Video
The virtual reality tumour map that could revolutionise cancer treatment
In 2017, the IMAXT team was awarded £20 million by Cancer Grand Challenges, funded by Cancer Research UK. Through the Cancer Grand Challenges initiative, a global team of experts from fields as diverse as medicine,…
Sheona Scales - Head of Research, Cancer Grand Challenges
Blog
A global search for cancer's toughest challenges
We’re leading a global conversation to help shape our next round of funding, inviting the submission of ideas via our Online Ideas Portal from now until 28 November.   Here, Sheona Scales, Head of Research at Cancer…
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News
A new tool to probe mutational signatures – and the long-sought-after link between tobacco and bladder cancer
How a suite of advanced machine learning algorithms is finding new cancer-causing patterns of DNA damage Cancer Grand Challenges researchers and collaborators have identified four new mutational signatures, including a…
Image of Sara Wakeling and her daughter, Alice
Blog
"Our team’s work has hope written all over it”
Advocacy plays a major role in Cancer Grand Challenges. The team taking on our Solid Tumours in Children challenge includes six advocates, representing the voice of children and families affected by solid cancers and…
Discover header 2021-22
News
Discover: a year of scientific creativity 2022
Today we launch Discover: a year of scientific creativity – our annual progress magazine showcasing the power of global team science. Discover celebrates how our community is coming together, thinking differently and…
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Blog
An atlas of oesophageal cancer development
From the team taking on our Cancer Causes challenge, a new integrated atlas of the stromal and epithelial interactions that drive cancers associated with chronic inflammation provides a new way to understand cancer…
IMAXT header with image of 3D Tumour
Blog
An entirely new way to visualise tumours
Meet the global network of early-career researchers driving the development of cancer’s most intricate maps, as part of our 3D Tumour Mapping challenge.   The tumour ecosystem, a web of interactions between the tumour’…
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Blog
Refuting the dogma surrounding breast cancer risk
Non-invasive breast carcinomas have long been assumed to be the precursors of any invasive cancers that follow. But new findings, from the team taking on our Lethal vs Non-lethal challenge, indicate that around 1 in 5…